The p53 Transcriptional Network Influences Microglia Behavior and Neuroinflammation
نویسندگان
چکیده
منابع مشابه
[Microglia in neurodegenerative disorders and neuroinflammation].
Microglia often accumulate around degenerating neurons. These macrophage-like immune cells produce a variety of neurotoxic and neuroprotective factors. Thus, the accumulation of glia in various neurologic disorders does not reflect only gliosis, but likely results in an active contribution to neuroinflammation, neural degeneration, and cell regeneration. We previously showed that glutamate is t...
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Microglia are the primary immune cell in the brain and are postulated to play important roles outside of immunity. Administration of the dual colony-stimulating factor 1 receptor (CSF1R)/c-Kit kinase inhibitor, PLX3397, to adult mice results in the elimination of ~99% of microglia, which remain eliminated for as long as treatment continues. Upon removal of the inhibitor, microglia rapidly repop...
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PURPOSE The TP53 tumor suppressor gene encodes a sequence-specific transcription factor that is able to transactivate several sets of genes, the promoters of which include appropriate response elements. Although human cancers frequently contain mutated p53, the alleles as well as the clinical expression are often heterogeneous. Germ line mutations of TP53 result in cancer proneness syndromes kn...
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Neuroimmune regulation plays a major role in many facets of human health. In the last 30 years our understanding of this intricate relationship between the brain and immune system has progressed immensely. Pioneering work in the late 1980s and early 1990s began to establish an understanding of the bi-directional communication between these previously considered distinct systems, and its implica...
متن کاملThe impact of post-transcriptional regulation in the p53 network
The p53 transcription factor regulates the synthesis of mRNAs encoding proteins involved in diverse cellular stress responses such as cell-cycle arrest, apoptosis, autophagy and senescence. In this review, we discuss how these mRNAs are concurrently regulated at the post-transcriptional level by microRNAs (miRNAs) and RNA-binding proteins (RBPs), which consequently modify the p53 transcriptiona...
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ژورنال
عنوان ژورنال: Critical Reviews in Immunology
سال: 2015
ISSN: 1040-8401
DOI: 10.1615/critrevimmunol.v35.i5.40